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The corpus luteum substantially produces progesterone until the ninth week of pregnancy following, the trophoblasts improve progesterone production, to become the most extensive resource of this hormone after the 12th-week gestation. Progesterone provides the endometrial transition from a proliferative to the secretary stage, support embryo development and is vital to pregnancy maintenance. Firstly, progesterone was described as a molecular formula yet, only in the mid-1940s, Russell Marker begins to manufacture progesterone from diosgenin, derived from the Japanese plant Dioscorea tokoro. Progesterone is one of the steroids hormones, which performs an essential function in many tissues other than the reproductive system, like in the mammary gland, to prepare the glands for breastfeeding, the cardiovascular system, central nervous system and bones. Researcher in the Scientific Research Group and Member of the Association for Scientific Research of the IRIFIV-AISRG Group, Liverpool, England.Ĥ Member of the Association for Scientific Research of the IRIFIV-AISRG Group, Casablanca, Morocco.ĥ GYN OBT, Member of the Association for Scientific Research of the IRIFIV-AISRG Group, Casablanca, Morocco.Ħ PhD in Science in Genetic Specializing in Department of Medical Genetics National Institute of Health Rabat, Morocco Researcher in the ART IRIFIV Scientific Research Group, Casablanca, Morocco.ħ Laboratory IVF Algeria, Rotary Fertility Center, Member of the Association for Scientific Research of the IRIFIV-AISRG Group, Algiers, Algeria.Ĩ Laboratory of Physiopathology, Genetics Molecular and Biotechnology (PGMB), Faculty of Sciences Ain Chock, Research Center, Health and Biotechnology, University Hassan, Casablanca, Morocco.ĩ GYN OBT, Head of the Association for Scientific Research of the IRIFIV-AISRG Group, Casablanca, Morocco.

Senior Clinical Embryology and Assisted Reproduction, Deputy Executive Director and Administrative Coordinator of the Association for Scientific Research of the IRIFIV-AISRG Group, Consultant in IRIFIV Fertility Center, IVF Laboratoy, Casablanca, Morocco.Ģ Head of the LABOMAC Laboratory and IRIFIV Fertility Center, AFC Fertility Center, Casablanca, Morocco.ģ UK. Senhaji 5, Abdelhafid Natiq 6, Romaissa Boutiche 7, Modou M.

Mustafa Zakaria 1*, Noureddine Louanjli 2, Aya Al-ibraheemi 3, Mohamed Ennaji 4, Wassym R.